Development of a low-stress blood pump

Cardiovascular diseases are among the most frequent causes of death worldwide. Blood pumps for mechanical cardiac support are already successfully used in the clinic for the treatment of myocardial diseases. However, the trauma of the blood in the pump flow often leads to a disturbance of the coagulation system and thus to bleeding complications for the patients.

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Aim

Effect of the pressure gradient in aortic stenosis on the Von Willebrand factor [Vincentelli 2003]. At high pressure gradient, the proportion of high molecular weight components of this factor decreases in blood.

The goal of this research project is the development of a low-stress rotary blood pump. There is a correlation between the high shear stressing of the blood in the pump and the damage of a protein that is important for the coagulation process – the Von Willebrand factor. This is observed in a stenosis of the aortic valve where a pressure gradient of 30 mmHg already results in a reduction of the high-molecular-weight multimers of this clotting factor.

Therefore, the project aims at generating the pressure build-up by the pump with the aid of new approaches in such a way that the pressure gradient remains below this threshold.

Results

The two-stage semiaxial cardiac support pump Careflow

In the course of the project, a two-stage semiaxial cardiac support pump was developed and manufactured together with Dualis MedTech.

Cooperation partners

  • Dualis MedTech

Literature

Vincentelli, A. ; Susen, S. ; Le Torneau, T. ; Six, I. ; Fabre, O. ; Juthier, F. ; Bauters, A. ; Decoene C. ; Goudemand, J. ; Prat, A. ; Jude, B.: Acquired von Willebrand Syndrome in Aortic Stenosis. In: The New England Journal of Medicine 349 (2003), no. 4, pp. 343–349

Funding

The project is funded by the German Federal Ministry of Education and Research as part of the KMU-innovativ program (promotional reference 01EZ120B).