Development of a low-stress blood pump
Cardiovascular diseases are among the most frequent causes of death worldwide. Blood pumps for mechanical cardiac support are already successfully used in the clinic for the treatment of myocardial diseases. However, the trauma of the blood in the pump flow often leads to a disturbance of the coagulation system and thus to bleeding complications for the patients.
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The goal of this research project is the development of a low-stress rotary blood pump. There is a correlation between the high shear stressing of the blood in the pump and the damage of a protein that is important for the coagulation process – the Von Willebrand factor. This is observed in a stenosis of the aortic valve where a pressure gradient of 30 mmHg already results in a reduction of the high-molecular-weight multimers of this clotting factor.