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2023

Shahryari M, Keller S, Meierhofer D, Wallach I, Safraou Y, Guo J, Marticorena Garcia SR, Braun J, Makowski MR, Sack I and Berndt N.
On the relationship between metabolic capacities and in vivo viscoelastic properties of the liver.
Front. Bioeng. Biotechnol. 2023;10:1042711

2022

Berndt N*, Hudert CA*, Eckstein J, Loddenkemper C, Henning S, Bufler P, Meierhofer D, Sack I, Wiegand S, Wallach I, Holzhütter HG.
Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease.
Int J Mol Sci. 2022 Sep 21;23(19):11072.

Maechler M, Rösner J, Wallach I, Geiger JRP, Spies C, Liotta A*, Berndt N*.
Sevoflurane Effects on Neuronal Energy Metabolism Correlate with Activity States while Mitochondrial Function Remains Intact.
Int J Mol Sci. 2022 Mar 11;23(6):3037.

*shared first or last authorship

2021

Berndt N, Eckstein J, Heucke N, Wuensch T, Gajowski R, Stockmann M, Meierhofer D, Holzhütter HG.
Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment.
FEBS J. 2021 Apr;288(7):2332-2346.

Berndt N, Eckstein J, Wallach I, Nordmeyer S, Kelm M, Kirchner M, Goubergrits L, Schafstedde M, Hennemuth A, Kraus M, Grune T, Mertins P, Kuehne T, Holzhütter HG.
CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases.
Circulation. 2021 Dec 14;144(24):1926-1939. Supplemental Material

Berndt N*, Kolbe E*, Gajowski R, Eckstein J, Ott F, Meierhofer D, Holzhütter HG*, Matz-Soja M*.
Functional consequences of metabolic zonation in murine livers: New insights for an old story.
Hepatology. 2021 Feb;73(2):795-810.

Berndt N, Kovács R, Schoknecht K, Rösner J, Reiffurth C, Maechler M, Holzhütter HG, Dreier JP, Spies C, Liotta A.
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact.
J Cereb Blood Flow Metab. 2021 Oct;41(10):2640-2655.

Garczynska K, Tzschätzsch H, Assili S, Kühl AA, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J.
Effect of Post-mortem Interval and Perfusion on the Biophysical Properties of ex vivo Liver Tissue Investigated Longitudinally by MRE and DWI.
Front. Physiol. 2021 Aug 3;12:696304.

Holzhütter HG, Berndt N.
Computational Hypothesis: How Intra-Hepatic Functional Heterogeneity May Influence the Cascading Progression of Free Fatty Acid-Induced Non-Alcoholic Fatty Liver Disease (NAFLD).
Cells. 2021 Mar 5;10(3):578.

Schreyer S, Berndt N, Eckstein J, Mülleder M, Hemmati-Sadeghi S, Klein C, Abuelnor B, Panzel A, Meierhofer D, Spranger J, Steiner B, Brachs S.
Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis.
Aging (Albany NY). 2021 Apr 16;13(8):10891-10919.

*shared first or last authorship

2020

Berndt N.
Modeling of liver metabolism.
Habilitation, Charité – Universitätsmedizin Berlin, 2020-05-25

Berndt N*, Egners A*, Mastrobuoni G*, Vvedenskaya O, Fragoulis A, Dugourd A, Bulik S, Pietzke M, Bielow C, van Gassel R, Damink SWO, Erdem M, Saez-Rodriguez J, Holzhütter HG*, Kempa S*, Cramer T*.
Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Br J Cancer. 2020 Jan;122(2):233-244.

Berndt N, Kovács R, Rösner J, Wallach I, Dreier JP, Liotta A.
Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia.
Int J Mol Sci. 2020 Jun 1;21(11):3977.

Garczyńska K, Tzschätzsch H, Kühl AA, Morr AS, Lilaj L, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J.
Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy.
Front Physiol. 2020 Nov 23;11:605205.

Holzhütter HG, Wuensch T, Gajowski R, Berndt N, Bulik S, Meierhofer D, Stockmann M.
A novel variant of the 13C-methacetin liver function breath test that eliminates the confounding effect of individual differences in systemic CO2 kinetics.
Arch Toxicol. 2020 Feb;94(2):401-415.

Kespohl M, Bredow C, Klingel K, Voß M, Paeschke A, Zickler M, Poller W, Kaya Z, Eckstein J, Fechner H, Spranger J, Fähling M, Wirth EK, Radoshevich L, Thery F, Impens F, Berndt N, Knobeloch K-P, Beling A.
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.
Science Advances. 2020 Mar 11;6(11):eaay1109.

*shared first or last authorship

2019

Berndt N, Eckstein J, Heucke N, Gajowski R, Stockmann M, Meierhofer D, Holzhütter HG. 
Characterization of Lipid and Lipid Droplet Metabolism in Human HCC.
Cells. 2019 May 27;8(5):512.

Berndt N, Patzak A, Holzhütter HG.
Metabolic Modeling of Kidney Diseases: Lessons learned from the Liver.
Acta Physiol (Oxf). 2019 Oct;227(2):e13350.

Hudert CA, Selinski S, Rudolph B, Bläker H, Loddenkemper C, Thielhorn R, Berndt N, Golka K, Cadenas C, Reinders J, Henning S, Bufler P, Jansen PLM, Holzhütter HG, Meierhofer D, Hengstler JG, Wiegand S.
Genetic determinants of steatosis and fibrosis progression in pediatric non-alcoholic fatty liver disease.
Liver Int. 2019 Mar;39(3):540-556.

Schneider J*, Berndt N*, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O.
Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.
J Cereb Blood Flow Metab. 2019 May;39(5):859-873.

*shared first or last authorship

2018

Berndt N, Bulik S, Holzhütter HG.
Corrigendum to "Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced alpha-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species."
Int J Cell Biol. 2018 Sep 9;2018:6139262.

Berndt N, Bulik S, Wallach I, Wünsch T, König M, Stockmann M, Meierhofer D, Holzhütter HG.
HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.
Nat Commun. 2018 Jun 19;9(1):2386.

Berndt N, Holzhütter HG.
Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones.
Front Physiol. 2018 Dec 12;9:1786.

Berndt N, Horger MS, Bulik S, Holzhütter HG.
A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.
PLoS Comput Biol. 2018 Feb 15;14(2):e1006005.

Berndt N, Rösner J, Haq RU, Kann O, Kovács R, Holzhütter HG, Spies C, Liotta A.
Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices.
Arch Toxicol. 2018 Oct;92(10):3191-3205. 

Eckstein J, Holzhütter HG*, Berndt N*.
Correction: The importance of membrane microdomains for bile salt-dependent biliary lipid secretion.
J Cell Sci. 2018 Mar 19;131(6):jcs217414.

Eckstein J, Holzhütter HG*, Berndt N*.
The importance of membrane microdomains for bile salt-dependent biliary lipid secretion.
J Cell Sci. 2018 Mar 1;131(5):jcs211524.

Kovács R, Gerevich Z, Friedman A, Otáhal J, Prager O, Gabriel S, Berndt N.
Bioenergetic Mechanisms of Seizure Control.
Front Cell Neurosci. 2018 Oct 8;12:335.

*shared first or last authorship

2008-2017

2017

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.
Oncotarget, 2017. 8(62): p. 105882-105904.

Schoknecht K*, Berndt N*, Rösner J, Heinemann U, Dreier JP, Kovács R, Friedman A, Liotta A.
Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.
Int J Mol Sci. 2017 Sep 7;18(9):1925.

Wallstab C, Eleftheriadou D, Schulz T, Damm G, Seehofer D, Borlak J, Holzhütter HG, Berndt N.
A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis.
FEBS J. 2017 Oct;284(19):3245-3261.

2016

Berndt N, Holzhütter HG.
Mathematical Modeling of Cellular Metabolism.
Recent Results Cancer Res, 2016. 207: p. 221-32. 

Bulik S, Holzhütter HG, Berndt N.
The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism - insights from mathematical modeling.
BMC Biol. 2016 Mar 2;14:15.

2015

Berndt N, Kann O, Holzhütter HG.
Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of temporal NAD(P)H fluorescence profiles.
J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506.

Eckstein J, Berndt N*, Holzhütter HG*.
Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion.
PLoS Comput Biol, 2015. 11(2): p. e1004033.

Zeigerer A, Bogorad RL, Gilleron J, Sharma K, Seifert S, Sales S, Berndt N, Bulik S, D'Souza RCJ, Marsico G, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Shevchenko A, Mann M, Holzhütter HG, Koteliansky V, Zerial M.
Regulation of liver metabolism by the endosomal GTPase Rab5.
Cell Rep, 2015. 11(6): p. 884-92.

2013

Berndt N, Holzhütter HG.
The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy.
Cell Biochem Biophys. 2013 Nov;67(2):527-35.

Berndt N, Holzhütter HG, Bulik S.
Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis.
FEBS J. 2013 Oct;280(20):5080-93.

Huchzermeyer C*, Berndt N*, Holzhütter HG*, Kann O*.
Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.
J Cereb Blood Flow Metab. 2013 Feb;33(2):263-71.

König M., Holzhütter HG., Berndt N.
Metabolic Gradients as Key Regulators in Zonation of Tumor Energy Metabolism: A Tissue-scale Model Based Study.
Biotechnol J. 2013 Sep;8(9):1058-69.

2012

Berndt N.
Theoretische Untersuchungen zur Kopplung von neuronaler Erregung und neuronalem Energiestoffwechsel.
Dissertation, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012-11-07

Berndt N, Bulik S, Holzhütter HG.
Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced Α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species.
Int J Cell Biol. 2012;2012:757594.

2011

Berndt N, Hoffmann S, Benda J, Holzhütter HG.
The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model.
J Theor Biol. 2011 May 7;276(1):42-9.

2009

Binder B, Goede A, Berndt N, Holzhütter HG.
A conceptual mathematical model of the dynamic self-organisation of dinstinct cellular organelles.
PLoS One. 2009 Dec 30;4(12):e8295.

2008

Berndt N, Rendall AD.
Isotropization in the approach to big rip singularities for Cardassian models.
Classical and Quantum Gravity, 2008. 25(14).

*shared first or last authorship