Projects

Please find here a list of recently funded projects of the institute.

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Projects

Title

Short description

Coworker

Cooperation partner

Berliner Zentrum für Maschinelles Lernen

The BMBF-funded competence centre aims at the systematic and sustainable expansion of interdisciplinary machine learning research, both in proven research constellations and in new, highly topical scientific objectives that have not yet been jointly researched. The Institute is working on AP17: Assessment of Cardiac Muscle Regeneration from Images and Proteomics.

Anja Hennemuth, Alexander Meyer, Titus Kühne

TU Berlin
Fraunhofer HHI
Zuse-Institut Berlin
FU Berlin
Universität Potsdam
WIAS Berlin
Max-Planck-Institut für Wissenschaftsgeschichte
Max-Planck-Institut für Molekulare Genetik
MDC
DHZB
HU Berlin

Bilddatenmanagementsystem des DZHK - Berlin

The central image data management system at the German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung, DZHK) is designed to ensure a standardized, quality-assured and efficient management of biomedical image data in the studies conducted by the DZHK and represents an important infrastructure component in the DZHK.

Titus Kühne, Jens Schaller

DZHK
Klinikum der Universität München / Institut für Klinische Radiologie
Universitätsmedizin Göttingen / Institut für Medizinische Informatik
Universitätsmedizin Göttingen / Institut für Diagnostische und Interventionelle Radiologie
Universitätsmedizin Greifswald / Unabhängige Treuhandstelle

DSSMitral - Decision Support Software für die Therapie von Mitralklappenerkrankungen

A software is to be developed which supports the physician in choosing the optimal treatment method. The software should allow the virtual simulation of real operations and interventions. The change in cardiac function and hemodynamics due to a planned operation should be predicted.

Titus Kühne, Ulrich Kertzscher, Leonid Goubergrits, Anja Hennemuth, Hanieh Mirzaee, Lennart Tautz, Katharina Vellguth, Faniry Razafindrazaka, Florian Hellmeier, Jan Brüning

Fraunhofer MEVIS
Deutsches Herzzentrum Berlin

ArtiCardio - KI-basierte digitale Therapieunterstützung für die Kardiologie, Teilvorhaben: "Bildbasierte Modellierung der Hämodynamik bei kardiovaskulären Erkrankungen"

It aims to provide decision support software for the treatment of aortic stenosis and cardiac valve diseases based on form-function linking with the application of three technologies: numerical fluid mechanics, statistical form models and machine learning

Titus Kühne, Leonid Goubergrits

1000shapes
Siemens Healthcare GmbH

HEIBRiDS - Doctoral Program in Data Science

HEIBRiDS focuses on data science from medicine and geo-sciences to information technology and engineering and provides an internationally highly recognized and vivid research environment within these research areas combined with the supervision by an interdisciplinary team and a rich lecture program.

Titus Kühne

6 Helmholtz-Centers (AWI, DESY, DLR, GfZ, HZB and MDC) in and around Berlin in cooperation with the Einstein Center for Digital Future involving the Berlin universities Charité, FU, HU, TU, and UdK

Entwicklung von experimentellen und numerischen Modellen der Plättchenanlagerung

The aim of the project is to characterize platelet deposition under fluid flow as the beginning of thrombosis.

Klaus Affeld, Ulrich Kertzscher, Felix Hehnen, Sarah Smatty

 

Computer unterstützte Analyse und Vorhersage des haemodynamischen Ergebnisses von Behandlungsstrategien bei Angeborenen Herzfehlern II

The aim of the project is to develop personalized diagnostic-prognostic methods for patients with congenital heart defects based on innovative cardiac imaging, biofluid mechanics and computer modelling.

Leonid Goubergrits, Kay Brosien, Marcus Kelm, Kilian Runte, Florian Hellmeier, Jan Brüning

Deutsches Herzzentrum Berlin

GlycoVAD - Entwicklung von Herzunterstützungssystemen mit einer antithrombogenen Beschichtung auf der Basis von Polyglycerinen

The aim of the project is to prevent thrombosis on blood pumps by means of a new type of coating.

Klaus Affeld, Ulrich Kertzscher, Tim Bierewirtz, Felix Hehnen, Sarah Smatty

Berlin Heart
FU Berlin, Institut für Chemie und Biochemie

RadialisPeriOP - Belastungsarme Ermittlung von Vitalparametern auf der Basis der Flussmessung in der Handgelenksarterie

One aim of this subproject is to design and manufacture essential components of a novel method of measuring blood pressure at the wrist artery. A further objective of this sub-project is the simulator for the research and testing of these components. System integration then follows.

Klaus Affeld, Ulrich Kertzscher, Paul Geus

Gampt
TU Berlin Fachgebiet Regelungssysteme
LB Engineering
Universitätsklinikum Gießen-Marburg Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerztherapie
DHZB

Folgeantrag miniVAD II Herzunterstützungssysteme

New technical and clinical approaches for the realization of cost-oriented VAD therapy II

Klaus Affeld, Ulrich Kertzscher, Michael Lommel

Berlin Heart
FU Berlin, Institut für Chemie und Biochemie

Entwicklung eines optischen Mikroringsensors zur quantitativen Bestimmung von Elektrolyten OptION

The aim of the project is to investigate an optical microring sensor for the quantitative determination of electrolyte concentrations in human blood samples.

Klaus Affeld, Ulrich Kertzscher

Eschweiler GmbH & Co. KG
Fraunhofer HHI
Scienion
Charité Laboratoriumsmedizin

Neuartige Sonde zur in vivo Isolierung von zirkulierenden Endothelzellen für die Diagnose und Verlaufskontrolle von kardiovaskulären Erkrankungen

Ziel des Projektes ist die Erforschung einer Sonde, die die Isolierung von zirkulierenden Endothelzellen (CEC) in vivo direkt aus dem Blut des Patienten ermöglicht. Das Identifizieren seltener CEC ist ein neuer, zuverlässiger Biomarker, der mit Endothelschäden assoziiert ist. Aus klinischer Sicht sind diese Endothelzellen wichtige Indikatoren für pathologische Prozesse im Körper und können daher zur Diagnose und Verlaufskontrolle von verschiedenen kardiovaskulären Erkrankungen eingesetzt werden.

Ulrich Kertzscher, Leonid Goubergrits

INVICOL GmbH
Beuth Hochschule für Technik Berlin / Labor für den Computereinsatz in der Produktion

EVOLchip - Vorhersage der Antibiotikaresistenz für eine nachhaltige Antibiotika-Behandlung

The aim of the EvolChip project is to develop a device that simulates the development of resistances. In addition, the effectiveness of dynamic antibiotic combinations can be investigated. This helps to avoid the development of resistances and to give therapy recommendations. There is currently no commercial device that predicts future resistances. EvolChip models the pharmacokinetic situation in patients better than previously available processes.

Vera Froese, Malte Mütter

FU Berlin, AG Rolff - Evolutionsbiologie

DiANa - Digitale Analyse der Nasenatmung

The aim is the phenotyping of nasal respiration on the basis of the analysis of nasal geometry, pressure loss and wall shear stress with the application of numerical fluid mechanics and statistical form models.

Leonid Goubergrits, Jan Brüning, Anja Hennemuth, Thomas Hildebrandt

Konrad Zuse Institut
1000shapes

Morphometrie und Hämodynamik von zerebralen Aneurysmen

Prediction of the risk of rupture of cerebral aneurysms based on morphometric and hemodynamic analysis. Optimization of treatment strategies (Coils, Clips, Flow Diverter, Huntarian Ligation).

Leonid Goubergrits, Jan Brüning, Jens Schaller, Florian Hellmeier

Helios Klinikum Berlin-Buch, Neurochirurgie

Software Assistance for Interventional Radiology and Cardiology

We develop a software platform that simplifies the preparation, simulation and monitoring of minimally invasive, cardiovascular and percutaneous procedures. Our goal is to help physicians to perform catheter and needle interventions more accurately and to achieve improvements for patients and the health care system. Our work includes innovative hardware to improve instrument navigation using sensor and robot technologies.

Hanieh Mirzaee, Andreas Schreiber

Fraunhofer MEVIS
Fraunhofer IPA

DFG Carotis Plaque

The aim of the project is to investigate individual risk factors for strokes caused by pathological changes of the carotid arteries. To this end, methods for the analysis of vessel properties such as hemodynamics and the structure of the vessel wall are being developed on the basis of innovative MRI protocols.

Anja Hennemuth, Lilli Kaufhold

Fraunhofer MEVIS
Universitätsklinikum Freiburg

Gewebeklassifikation und Machine Learning

With the aid of machine-learning, plaque components in carotid plaque are automatically detected and analyzed.

Hanieh Mirzaee, Lilli Kaufhold, Anja Hennemuth

Fraunhofer MEVIS
Universitätsklinikum Freiburg

Bildbasierte Bewegungsanalyse

We investigate the motion analysis of cardiac structures such as heart valves and septum in time-resolved image data as a supporting component in diagnosis and therapy planning. The analysis should enable the tracking and segmentation of structures as well as the characterisation of their movement.

Lennart Tautz, Anja Hennemuth

Fraunhofer MEVIS
Deutsches Herzzentrum Berlin
Universitätsmedizin Göttingen
Max-Planck-Institut für biophysikalische Chemie Göttingen
New York University

Bildbasierte Analyse der Hämodynamik

In order to derive information about blood flow, pressure distribution, connectivity, etc. from phase contrast MRI image data, preprocessing, analysis and visualization methods are developed here.

Hanieh Mirzaee, Anja Hennemuth

Universitätsklinikum Freiburg
Universitätsklinikum Schleswig-Holstein
Deutsches Herzzentrum München
Inselspital Bern
Northwestern University Chicago

Mobile Anwendungen und Cloud-Computing in der bildbasierten Medizin

Integration of visualization and analysis techniques of medical image data into mobile and distributed applications to support diagnostics, therapy planning and clinical studies

Peter Kohlmann

Fraunhofer MEVIS

Softwaretechnologien für bildbasierte klinische Anwendungen

Concepts for the use of agile software development in the field of applied research, prototyping and product development, e. g. with the MeVisLab platform

Jan-Martin Kuhnigk

Fraunhofer MEVIS

e:Med SMART - Systems Medicine of Heart Failure

The overall goal of SMART is to implement methods to individually predict the efficacy of aortic valve stenosis treatment.

Titus Kühne, Sarah Nordmeyer

Bayer Technology Services
Deutsches Herzzentrum Berlin
Max-Delbrück Center
Hasso-Plattner-Institut

My Health My Data

MyHealthMyData (MHMD) aims at introducing a new way to share private information and empower their primary owners, the patients. MHMD will foster the development of a true information marketplace, enabling individuals to exercise full control over their personal data and leverage their value, implementing new mechanisms of trust and direct, value-based relationships between EU citizens, hospitals, research centres and businesses.

Titus Kühne

Lynkeus, Athena Research and Innovation Center, IEIIT-CNR group, Digi.me, Gnúbila, HES-SO (University of Applied Sciences Western Switzerland), Panetta & Associati, SBA Research, Siemens Healthcare, Transilvania University of Braşov, Charité, Ospedale Pediatrico Bambin Gesù, Queen Mary University London, University College of London

EurValve - Personalised Decision Support for Heart Valve Disease

EurValve will implement, test and validate a modelling based decision support system (DSS) for aortic and mitral valve diseases that allows simulating, comparing and understanding the effects (outcomes) and risks of different treatment strategies. In addition, the DSS will improve knowledge of disease mechanisms by applying a holistic assessment of cardiovascular function that includes haemodynamic data at all cardiovascular compartments (ventricle, valve, vessels) and multiscale components that couple organ with cell function.

Marcus Kelm

University of Sheffield
ANSYS
Catharina Hospital in Eindhoven
Academic Computer Centre CYFRONET
Université de Rennes
Max Delbrück Center for Molecular Medicine
Philips
Sheffield Teaching Hospitals
Therenva
Eindhoven University of Technology
University of Bristol